Development of Lung Organoids from Cystic Fibrosis Patients to Study Immune Responses

Development of Lung Organoids from Cystic Fibrosis Patients to Study Immune Responses to Pseudomonas aeruginosa and Aspergillus fumigatus Co-Infections

Summary

Developing lung organoids from cystic fibrosis patients to study how the immune system responds to co-infection with Pseudomonas aeruginosa and Aspergillus fumigatus, aiming to uncover new therapeutic targets.

How are we doing it?

I’ll use stem cells to grow mini lungs in the lab, then infect them with Pseudomonas and Aspergillus. I’ll study how the lung cells respond by looking at which genes are turned on or off, and work with experts in lung health and infections to make sure the results are meaningful for patients.

What happens next?

Once we’ve collected the data, we’ll use it to plan larger studies and apply for more funding. We’ll also share the findings with doctors and patient groups to help improve treatment and care for people with cystic fibrosis.

Funding

NIHR Exeter BRC.

People Involved

Prof. Adilia Warris and Prof Chris Scotton.