Lettie is an NIHR Academic Clinical Lecturer in Clinical Genetics working with the Exeter Rare Disease Genomics Research Group. Her research interests include identifying the genomic and molecular causes of rare genetic conditions, with a particular focus on neurodevelopmental disorders and the translation of research findings into benefits for patients through improved clinical diagnosis, testing and treatment strategies. Lettie's research also aims to identify potential therapeutic targets for these conditions and development of clinical trials of novel treatments, including drug repurposing.