Research projects

We help to progress high-quality translational research across our theme areas, addressing the most pressing health issues for our communities

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Showing 58 research projects

Using whole genome sequencing to identify non-coding elements associated with common, complex phenotypes

Genetics and Genomics

Understanding the role in disease development of the non-coding genome to help improve treatments

Analysis of extracellular vesicle cargo as biomarkers to differentiate Alzheimer’s disease and dementia with Lewy bodies

Neurodegeneration

Understanding and tracking changes in the brain during neurodegeneration to help improve treatments

Investigating the aetiology of non-autoimmune young-onset diabetes in sub-Saharan Africa.

Diabetes

Understanding the causes of an unusual form of diabetes in young people in sub-Saharan Africa

Personalised Pulmonary Rehabilitation: Harnessing the power of Cardiopulmonary Exercise Testing (CPET)

Rehabilitation

Improving care for ageing patients with chronic respiratory disease

Identification of novel therapeutic targets for TDP-43 proteinopathies

Neurodegeneration

Improving therapies for neurodegenerative diseases

Commensal Fungi in the Lung: Innocent Bystanders or Pathogenic Orchestrators of Severe Asthma?

Clinical mycology

Investigating the relationship between the lung microbiome and severe asthma

Developing a Novel Genomic Biomarker for the Early Detection of Neurodegeneration

Neurodegeneration

Improving early diagnosis of neurodegenerative disease

Cryptococcus-Mycobacterium interactions: Framework for a co-infection model

Clinical mycology

Investigating the effects of co-infection of Cryptococcus and Mycobacterium on patients

Platform for Online Recruitment, Triage and Assessment for Brain Health Research (Brain Health PORTAL)

Neurodegeneration

Creating a new digital resource for brain health research in adults

The VITAL Study

Neurodegeneration

Assessing at-home blood testing to help detect Alzheimer’s and related diseases in older adults.

Using brain cells to treat diabetes

Diabetes

Exploring the role of insulin and islet protection factors released from stem cell derived neural cells to help improve treatment for diabetes

Assessing Cancer Predisposition in UK and Iceland Populations using whole genome sequencing

Genetics and Genomics

Using large genomic datasets to evaluate the impact of pathogenic genetic variants on a person’s likelihood of developing cancer